https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22168 -/-) BALB/c mice were intranasally sensitised and challenged with HDM prior to infection with RV1B. In some experiments, mice were administered recombinant IFN or adoptively transferred with plasmacytoid dendritic cells (pDC). Results: Allergic Tlr7-/- mice displayed impaired IFN release upon RV1B infection, increased virus replication and exaggerated eosinophilic inflammation and airways hyper reactivity. Treatment with exogenous IFN or adoptive transfer of TLR7-competent pDCs blocked these exaggerated inflammatory responses and boosted IFNγ release in the absence of host TLR7 signalling. TLR7 expression in the lungs was suppressed by allergic inflammation and by interleukin (IL)-5-induced eosinophilia in the absence of allergy. Subjects with moderate-to-severe asthma and eosinophilic but not neutrophilic airways inflammation, despite inhaled steroids, showed reduced TLR7 and IFNλ2/3 expression in endobronchial biopsies. Furthermore, TLR7 expression inversely correlated with percentage of sputum eosinophils. Conclusions: This implicates IL-5-induced airways eosinophilia as a negative regulator of TLR7 expression and antiviral responses, which provides a molecular mechanism underpinning the effect of eosinophil-targeting treatments for the prevention of asthma exacerbations.]]> Wed 11 Apr 2018 15:36:21 AEST ]]> Blood interferon-a levels and severity, outcomes, and inflammatory profiles in hospitalized COVID-19 patients https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38147 Wed 04 Aug 2021 18:45:51 AEST ]]> Reduced antiviral interferon production in poorly controlled asthma is associated with neutrophilic inflammation and high-dose inhaled corticosteroids https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26090 Wed 02 Mar 2022 14:26:24 AEDT ]]> Conditionally reprogrammed asthmatic bronchial epithelial cells express lower FOXJ1 at terminal differentiation and lower IFNs following RV-A1 infection https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47290 Tue 30 Apr 2024 08:50:07 AEST ]]> Defining the distinct, intrinsic properties of the novel type I interferon, IFNϵ. https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42974 Tue 14 May 2024 11:55:54 AEST ]]> Cladribine versus fingolimod, natalizumab and interferon β for multiple sclerosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36736 Thu 02 Jul 2020 16:31:45 AEST ]]> Immunotherapy of distant metastatic disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7353 Sat 24 Mar 2018 08:40:18 AEDT ]]> Development of thyroid diseases in the treatment of chronic hepatitis C with alpha-interferon may be a good prognosticator in achieving a sustained virological response: a meta-analysis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8319 Sat 24 Mar 2018 08:36:54 AEDT ]]> Utility of adjuvant systemic therapy in melanoma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7954 Sat 24 Mar 2018 08:34:57 AEDT ]]> Increased SARS-CoV-2 Infection, Protease, and Inflammatory Responses in Chronic Obstructive Pulmonary Disease Primary Bronchial Epithelial Cells Defined with Single-Cell RNA Sequencing https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51768 Mon 18 Sep 2023 14:30:32 AEST ]]> Toll-like receptor 7 is reduced in severe asthma and linked to an altered microRNA profile https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24497 Ex vivo knockdown of these microRNAs restored TLR7 expression with concomitant augmentation of virus-induced IFN production. Conclusions: In severe asthma, TLR7 deficiency drives impaired innate immune responses to virus by AMs. Blocking a group of microRNAs that are up-regulated in these cells can restore antiviral innate responses, providing a novel approach for therapy in asthma.]]> Fri 01 Apr 2022 09:26:07 AEDT ]]>